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COLCHICINE (Mechanism of action (Colchicine inhibits microtubule…
COLCHICINE
Mechanism of action
Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, so colchicine effectively functions as a "mitotic poison" or spindle poison
Indications
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• Familial mediterranean fever,
• Gonadal dysgenesis (turner syndrome),
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• Recurrent miscarriage (habitual abortion),
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Contraindications
Colchicine is contraindicated in conditions like Blood dyscrasias,Renal diseases,GI diseases,Cardiac disease.
Storage Condition
Store at room temperature. Do not Freeze. Protect from Sunlight.
Store in a well closed container, Below 40°C. Protect from Sunlight
Side Effects
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• Cardiovascular collapse,
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