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Coagulation pathway (Thrombin (Promotes platelet aggregation / release,…
Coagulation pathway
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Coagulation factors
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The majority of factors exist as pro enzymes, upon activation they are converted to active serine proteases
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Purpose
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Fibrin is an insoluble protein that forms a mesh over cut or lesion & strengthens platelet aggregation
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Activated FIXa serine protease will cleave peptide of FX freeing active site making FXa serine protease
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Role of calcium
binding to a coagulation protein is important to orientate coagulation factors to improve protein to protein interactions
FII, FVII, FIX & FX, protein c and S are all modified in the liver by gamma carboxylation
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