Nitroglycerin Variant or Prinzmetal’s (Side Effects (Headache,…
Variant or Prinzmetal’s
Mechanism of Action
The increase in cGMP that is produced by the release of nitric oxide result in a decrease in platelet aggregation
Nitroglycerin produces a dose related dilation of both arterial and venous bed
Relaxes smooth muscle of epicardium coronary arteries and reduces coronary artery spasm.
Decrease smooth muscle contractile result from lowering of intracellular calcium and desensitatization of myosin light chain (a contractile protein) to the effect of calcium
Type 5 PDE inhibitors potentiate the action of nitrates used for angina: 24hours of taking sildenafil is likely to produce hypotension.
Interaction with tadafil lasts up to 48 hours
Hypotension or uncorrected hypovolaemia
In adequate cerebral function.
Angina of effort
Storage condition-Store in a Cool Dry place
Route Of Administration