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Platelets (Overview (Platelets are disc shaped cells that are anucleate…
Platelets
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Function
Adhesion
in vivo, damage to the vessel wall causes exposure of the subendothelial fibres.
platelets rapidly cover this area and the adhesion is dependent upon integrins such as GP Ib, GP Ia and GPIIIa/IIIb along with Von Williebrands factor
Shape Change
adhesion is accompanied by a shape change from discoid to irregular projections, reversible at first but along with granule release becomes irreversible
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Aggregation
initiated by
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Collagen, Adrenalin, thromboxane A2 (TXA2) ,
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clump together to form primary plug which is unstable & breaks down if not reinforced (normally done with fibrin)
Canalicular system
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platelets respond to many stimuli which cause shape change, degranulation and aggregation
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