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RADIOTHERAPY (Approaches to increase therapeutic index (Altered…
RADIOTHERAPY
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side effects
Systemic
- nausea, vomiting, fever, dizziness, fatigue, anorexia, anemia, immunosuppression, mutagenic effects
Local
- Acute: skin reactions, mucositis
- Late: necrosis, fibrosis, fistula, ulceration, myelitis, cataract
5 R
- Repair of intracellular damage
- Redistribution of surviving cells
- Repopulation
- Reoxygenation
- Intrinsic radiosensitivity
Radiotherapy types
- Teletherapy: external beam irradiation
- Brachyterapy: isotope placed intracavitally or interstitially
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Palliative radiotherapy
selected indications
- Painful bone metastases
- Painful lesions at other locations
- Bleeding, dyspnea in advanced lung cancer
- Brain metastases
- Advanced head and neck cancer
- Advanced tumors of skin and soft tissues
- Advanced pelvic tumors
- Dysphagia related to mediastinal tumors and lung cancer
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