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Analgesics (Opioid analgesics (Tolerance (Different physiological response…
Analgesics
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Strong Agonists
Morphine
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DDI
Enhanced with benzodiazepines, MAOi and TCA
Meperidine/Pethidine
Binds to mu receptor well, also to kappa receptors
ADR
Large, continuous doses
Tremors, anxiety, muscle tremors
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Dry mouth, blurred vision (antimuscarinic effect)
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Fentanyl
Structurally related to meperidine, 80-100 stronger analgesic than morphine, used as GA
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Methadone
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Suppresses withdrawal, tolerance does not build easily
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ADR
Physical dependence like morphine, but less neurotoxic
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Opioid Antagonists
Naloxone
Competitive antagonist at all receptors (mu, kappa, delta)
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Non-opioid analgesics
Tramadol
Central acting analgesic
Used for moderate-severe pain, post-op pain
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Less respiratory depression, constipation and abuse potential
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