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Surfen TMZ Nanoparticle (PEG (Effect on circulation time (Circulation…

- - - - 5 kDa was best for avoidig protein adsorption with PLA NPs
      - Up to 20kDa gave good circulation times
  - - - PEG-polypropylene glycol-PEG tri-block co-polymer
      - Low Cytotoxicity
      - serves as a chemosensitizer
      - Associates with Cell wall
- - - - Nanoprecipitation to form NPs with PLGA (in oil phase) and F127 (in water phase) for a NP coated with PEG
    - - Use F68 (PEO-PPO-PEO) poloxamer
    - - Adding folate into the mix- read McNeilly Biomaterials paper. Do GBM specifically upregulate folate receptors/is this worth also putting ont he particle for targeting?
        
        Many cancer cells overexpress folate 100-300 times more than normal cells
- - - - 50/50
        
        Acid Terminated
        
        35kDa
    - - 1kDa
  - - - ~12kDa or less
    - - ~5kDa
    - - F127
        
        Gives PEG corona