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regub 6: effects of hyper + hypothyroidism 2 (goitre (sometimes in…
regub 6: effects of hyper + hypothyroidism 2
hyperthyroidism
causes
autoimmunity (Grave's) - most common
antibody = thyroid stimulating immunoglobulins
not subject to -ve feedback
mimic TSH
excess TRH/TSH
thyroid adenoma
symptoms
sweating
heat intolerance
increased appetite + food intake
weightloss
weakness
palpitations
excess mental alertness
irritable
tense
anxious
emotional
proptosis/exophthalmos
! dry eyes + corneal ulceration
inflamm of fat + muscles behind eyes
diagnostic tests
blood thyroxine
TSH
goitre
highly visible hypertrophy of thyroid gland
sometimes in hyperthyroidism
Grave's, hypothal/pit defect
sometimes in hypothyroidism
gland failure - iodine deficiency
only occurs when gland is excessively stimulated with TSH/TSI