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Vitamin B12 & Folate (Absorption (Pancreatic enzymes (trypsin) digests…

- - - - absorbed at terminal illeum and binds to protein trancobalamins
- - - - Tired
      - beefy tongue
      - pins & needles - neurological problems
- - - - then bi/tri phosphate to dna
  - - - DHF polyglutamate recycled into THF, methatrexate prevents this step for anticancer therapy, can be used in rheumatoid arthhritis
        
        Vit B12 or folate deficient cells can be macrocytic and in peripheral nlood
        
        have increased MCV >100fl but can be as high as 130
        
        Hb decreased