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Red Cell Metabolism (Production of 2,3-BPG (biphosphoglycerate)…

- - - - 2,3 -BPG to phosphglycerate via 2,3-BPG phosphotase
  - - - reduces affinity of O2 for Hb so oxygen more readily given up to tissues
        
        Foetal Hb has reduced affinity for 2,3-bpg so greater affinity for O2 than adult HbA
- - - - Co-operativity - binding of first O2 is rate dependent
        
        measured as hill constant myoglobin=1, heamoglobin = 3
- - - - H2O2
      - superoxide
      - if left unchecked can oxidise Hb leading to heinz body formation
        
        heinz bodies - oxidation of haem iron to Fe3+ and denaturation of globin chains