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Red Cell development (Stem cells (Blast cell primitive and in bone marrow,…
Red Cell development
Stem cells
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3 Progenitor cells; erythroid, granulocytes, megakaryocytes
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Production
During gestation the yolk sac is main site of production. After third month moves to liver and spleen
Infancy - all bone marrow haemotopoietic, myelofibrosis is deposition of fat in bone marrow so non functional and thus extra medullary erythropoesis takes place
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2 multipotent stem cells: common lymphoid/myeloid progenitor. give rise to myeloid and lymphoid lineage
Function/structure
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Structure - Biconcave, large SA to Vol ratio,
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