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haemolytic anaemia (symptoms (pallor, jaundice, dark urine, fatigue, SOB,…

- - - - excess of Hb in blood plasma
  - - - mechanical
        
        marching
        
        mechanical cardiac valve
      - blood transfusion reaction
    - - enzyme defects
        
        G6PD deficiency
        
        pyruvate kinase deficiency
- - - - hereditary spherocytosis
      - hereditary elliptocytosis
    - - immune
        
        haemolytic disease of newborn
      - autoimmune
        
        warm autoimmune heamolytic aneamia
        
        IgG
        
        body temperature
        
        cause
        
        idiopathic
        
        seconmadry to SLE or malignancy
        
        drugs - NSAIDs, cephalosporins
        
        cold autoimmune heamolytic anaemia
        
        IgM
        
        cold temperatures
        
        causes
        
        primary
        
        secondary
        
        Mycoplasma pneumoniae
        
        lymphoma
        
        infectious mononucleosis
        
        Cold agglutinin disease
      - non-immune
        
        DIC
        
        TTP
        
        thrombotic thrombocytopenic purpura