Please enable JavaScript.
Coggle requires JavaScript to display documents.
Lecture 35: Impact of Human Microbiome and its Relevance to Disease (Guest…
Lecture 35: Impact of Human Microbiome and its Relevance to Disease (Guest Lecture)
Host-Microbial Mutualism
Host benefits to bacteria
Intestinal mucus provides a source of nutrition
Provides a unique niche
Bacterial benefits to host
Fermentation of indigestible carbohydrates
Metabolism of drugs
Education of mucosal immune system
Nitrogen balance
Vitamin synthesis
Diabetes, atherosclerosis, asthma, colon cancer, inflammatory bowel disease all diseases possibly caused by microbiome malfunction
Mode of delivery affects microbiome concentration (C-section more heterogeneous)
Cessation of breastfeeding leads to "adult" microbiome development
Antibiotics can lead to obesity
A decrease in microbiota diversity (correlated w/ western diet) is associated with higher rate of disease
Three "enterotypes"- classifications of microbiome makeup. Associated with agrarian diet/ industrialization level
Many metabolites by bacteria are associated with disease, such as cardiovascular issues
Inflammatory bowel disease, ulcerative colitis, Crohn's disease, all mostly environmentally caused
Fecal transplant can help symptoms
Food And Resulting Microbial Metabolites (FARMM)