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Nutrition Iron (Intro (Iron is found in all cells within the body (Free…
Nutrition Iron
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Ferritin
Spherical, each molecule can store 5,000 ions in ferric state
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Uptake
Main site of uptake is duodenum, binds HCP-1 receptor on duodenal enterocytes
Non haem is less well absorbed, reduction is aided by vit C
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enterocyte have ferric reductase, reduces Fe to ferrous form before uptake into body
Transferrin
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Normal plasma contains enough transferrin to bind 300ug/dl. 33% saturated >15% deficient <60% overload
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Ferroportin
If the body has enough Fe liver produces hepsidin and FPN is marked for destruction via binding of hepsidin
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Reductase
Pancreatitis can't produce pancreatic fluids so pH not neutralised so pH not neutralised so ferrous iron in gut so overload of Fe
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Fate of Iron
Desquamination - shedding of enterocyte, due to v short half life
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