I don’t really care if I can make one particular area look nice, that isn’t very hard to do, what I care about is if I can mass produce similar graphics and art throughout dozens if not hundreds of locations in the entire game, and done in such way that I never have to go back in and optimize it. So when I begin building something, I will immediately take into account everything that could potential slow either me, the player, or the hardware down further down the line and I try to cover as much of it as I can right away.
In general everything has an impact on everything. If you build games you should always look at the entire picture and never do one thing independently of another.