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Gastritis (Treatment (Antacids-Alka seltzer, Maalox, Rolaids, Mylanta,…
Gastritis
Treatment
Antacids-Alka seltzer, Maalox, Rolaids, Mylanta, Riopan
H2 Blockers-cimetidine (Tagamet HB), famotidine (Pepcid AC), nizatidine (Axid AR), and ranitidine (Zantac 75)
Proton pump inhibitors-omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), dexlansoprazole (Dexilant), pantoprazole (Protonix), rabeprazole (AcipHex), and esomeprazole (Nexium)
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Epidemiology
Acute gastritis can be erosive-superficial, deep, hemorrhagic erosions and be caused by chronic NSAIDS use or alcohol use/misuse and reflux of bile salts or nonerosive-H. pylori
Globally, more than half of the population has chronic gastritis
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Autoimmune-mediated atrophic gastritis develops antibodies to the gastric parietal cells. Autoimmune disorder associated with autoimmune gastritis include thyroid disease, type 1 diabetes, idiopathic adrenocortical insufficiency, vitiligo, and hypoparathyroidism.
Diagnosis
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Other tests, upper GI series, blood tests-anemia or H. pylori, stool test-blood, urea breath test-H. pylori.
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Pathophysology
In autoimmune gastritis antiparietal cell bodies stimulate chronic inflammatory, mononuclear and lymphocytic infiltrate involving the oxynitic mucosa, leading to loss of parietal and chief cells in the gastric corpus
NSAIDs and alcohol decrease gastric mucosal flow with loss of the mucosal protective barrier. NSAIDS inhibit prostaglandin production and alcohol depletes sulfhydryl compounds in gastric mucosa.
Helicobactor pylori infection causes a severe inflammatory response with gastric mucin degradation and increased mucosal permeability, followed by gastric epithelial cytotoxicity
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