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Cholesterol absorption inhibitors (mechaniism of action (They act on the…
Cholesterol absorption inhibitors
mechaniism of action
They act on the brush border of intestines, cholesterol absorption inhibitors block the absorption of dietary cholesterol. Consequently, less cholesterol goes to the liver and it increases the cholesterol clearance to make up for the drop.
indications
Adjunct to diet and exercise as a monotherapy or in combination with HMG-CoA inhibitors or bile acid sequestrants.
Used in combination with statins to treat homozygous familial hypercholesterolemia.
contra indications
Liver disease, pregnancy, lactation :not used if combined with statins because of the effects of statins to these health conditions.
Allergy to cholesterol absorption inhibitors
side effects
CNS: dizziness, nausea and vomiting, fatigue
Respiratory: upper respiratory track infection
GI: mild abdominal pain
Musculoskeletal: muscle aches and back pain
storage conditions
stored away from direct sunlight, under room temperature
route of
dministration
oral
nursing considerations
Conduct thorough physical assessment before beginning drug therapy. To establish baseline status, determine effectivity of therapy and evaluate potential adverse effects.
Assess neurological status..
Assess closely patient’s heart rate and blood pressure. To identify cardiovascular changes that may warrant a change in drug dose.