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niacin (mechanism of action ((increase activity of lipase, which breaks…
mechanism of action
increase activity of lipase, which breaks down lipids
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- In large doses, it may produce vasodilatation that is limited to the cutaneous vessels. This effect seems to be induced by prostaglandins.
- Niacin also causes the release of histamine, which results in an increase in gastric motility and acid secretion.
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indications
-Effective in lowering triglyceride, total serum cholesterol, and LDL levels
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-Effective in the treatment of types IIa, IIb, III, IV, and V hyperlipidemias
contra indications
liver disease, hypertension, peptic ulcer and active hemorrhagic procress
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nursing considerations
Monitor blood glucose, obtain baseline liver function tests, monitor liver and kidney function, BUN, creatinine, I&O