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Gene Mutations (Effect (Missense (Forward (creates new allelic variants…
Gene Mutations
Effect
Nonsense
aa --> STOP
TAC --> TAA
UAC --> UAA
Tyr --> STOP
Missense
Forward
creates new allelic variants
AGTCCA --> AGCCCA
Reverse
original --> new --> original
2 mutations
equivalent
exact
back to exact same codon
ATC --> AGC --> ATC
neutral change in aa but similar chemistries
Gly --> Val
nonpolar --> nonpolar
TTT ---> TTA
UUU --> UUA
Phe --> Leu
Silent
no change in amino acid
TTT --> TTC
UUU ---> UUC
Phe --> Phe