FUN 24 ANTIBIOTICS - DNA/RNA SYNTHESIS INHIBITORS
DNA synthesis inhibitors
can't be used in childhood or pregnancy
bactericidal @ high concs
quinolone
4 generations
last 3 are fluoroquinolones
metronidazole for anaerobes
inhibit DNA gyrase
required for supercoiling
inhibit DNA type 4 topoisomerase
good oral bioavailability
best tolerated antibiotic
SEs = neuropathy + tendinitis (blackbox warning)
RNA synthesis inhibitors
rifamycins
inhibit DNA-dependent RNA polymerase
SEs = hepatotoxicty, fever, orange urine
NB in TB
never as mono therapy: resistance
anti-TB antibiotics
isoniazid - inhibits cell wall synthesis
rifampin - inhibits transcription
pyrazinamide - inhibits synthesis of short chain FA precursors