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Research Development (Treating Akinesia by PPN Stimulation (Jenkinson et…

- - - - one of the monkeys could use neural control to move the feedback cursor to different targets
  - - - Activity of M1 neurons in 3 monkeys using a UTAH array
      - used one hand to move a manipulandum that controlled the position of the cursor on the screen
      - linear filter method to recontruct trajectory and found it could accurately represent trajectory explaining 60% of the variance
      - at comparable times to hand signal
    - - neuronal activity from electrodes implanted in M1 of quadraplegic patient MN
      - recorded M1 activity during intended hand motion using decoders to create a neural cursor
      - MN successfully used the motor neural cursor to open simulated email and operate devices such as television, even while conversing
  - - - Restore grasp in monkeys using brain controlled stimulation
      - simulated paralysis by injecting them with anaesthetic to block nerves at the elbow
      - interpreted activity from the paralysed muscles and used these to control the intensity of stimulation to muscles
      - restored monkeys to voluntary control, measured in a functional grasping task: grasp ball and drop into tube.
    - - Intracortically recorded signals to record activity in M1
      - Used machine learning algorithms to decode neural activity and control activity in patient forearm using a neuromuscular electrical stimulation system providing isolated finger units and continuous cortical control of 6 different hand and wrist units
      - able to use the system to complete functional tasks related to daily living