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NSAIDS (Types (Propionic acid derivatives (Ibuprofen / naproxen (First…

- - - - First line for inflammatory arthropathies
  - - - Reduced GI effects
      - But increased risk of cardiovascular morbidity
  - - - Long half life --> but associated with GI bleeds in elderly
  - - - Potent but high incidence side effects
- - - - Inhibition of PGE2 and PGI2
        
        These usually increase gastric mucosa blood flow
        
        And decrease gastric acid production
    - - Decreased PG's = afferent arteriole vasoconstriction = decreased renal perfusion pressure
    - - Bonchospasm in asthmatics
        
        NOTE Samter's syndrome (triad)
        
        Aspirin sensitivity
        
        Asthma
        
        Nasal polyposis
    - - Rash / urticaria / photosensitivity
  - - - Irreversible inhibitor of of COX
        
        Acetylating serine residues in active site of enzyme
        
        Antiplatelet function as suppresses thromboxanes