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Autocoids (Histamine (H1 Antagonists = Antihistamines (Examples of 1st gen…

- - - - Dilates arterioles
      - Increases contractility & HR
    - - SM contracts
  - - - Chlorphenamine
      - Cyproheptadine
      - Diphenhydramine
      - Hydroxyzine
      - Promethazine
    - - Loratidine
      - Cetrizine
    - - Inhibition of itch, histamine induced vasodiation, capillary permeability, relaxation of SM, Relaxation of cotracted intestinal SM, sedation
    - - Allergic reactions - Pruritis, reactions, anaphylaxis
      - Antiemetic/motionsickness - No signals to the vomiting centre - See GI drugs
      - Sedation
    - - CNS depression
      - Antimuscarinic effects
      - Allergy to drugs/tolerance
- - - - Prostanoids
      - Leukotrienes