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Probes design in molecular imaging PET imaging: design and synthesis ➜…

- - - - Short half lives and high radiation energies (compared to general NM imaging)
      - Produced by cyclotron or generatiors
      - Positron emitting radionuclides
      - Principal positron Emitters
        (radionuclide - production -Physical T1/2)
        • Common problems: money and suppliers(cyclotron)
        
        C-11 Cyclotron 20 min
        
        N-13 Cyclotron 10 min
        
        O-15 Cyclotron 2 min
        
        F-18 Cyclotron 110 min
        
        Ga-68 Generator 68 min
        
        Zr-89 Cyclotron 78 h
    - - is there a molecule with relevant target affinity and suitability to serve as lead for te development as tracer?
      - does the tracer accumulation in vivo correlate with the biochemical process?➜ suitable animal models
      - can the imaging concept developed and validated in animals be translated to man?
      - the physicochemical behavior of the tracer in vivo should correspond with the half life of the isotope
      - is the target specific for the disease and can it be addressed by a radiolabeled probe?
    - - Click chemistry
      - New tips: MW
      - Regular chemistry
        
        Metal:chelator
        
        substitutions (I,F)
- - - - Over expression of membrane glucose transporter receptors, especially GLUT-1 and GLUT-3 on surface of cancer cells
      - Increased hexokinase activity
    - - Preclinical behavior
      - Preclinical Inflammation (macrophages)
      - Preclinical Infections
      - Clinical Epileptic foci in brain
      - Clinical Alzheimer´s disease (AD) and temporal dementia
      - Clinical Myocardial glucose metabolism, Tumor glucose metabolism