BILTRICIDE (Praziquantel) (SIDE EFFECTS (Gastro-intestinal and abdominal…
MECHANISM OF ACTION
Induces a rapid contraction of schistosomes by a specific effect on the permeability of the cell membrane.
The drug further causes vacuolization and disintergration of the schistosome tegument.
The effect is more marked on adult worms compared to young worms.
An incease calcium infux may play an important role.
Secondary effects are inhibition of glucose uptake, lowering of glycogen levels and stimulation of lactate release.
Indicated for the treatment of infection due to the following species of schistsom:(Schistosome haematobium, Schistosome japonicum, Schistosome mansoni, and Schistosome mekongi) and infections due to the liver flukes Clonorchis sinensis?Opisthorchis viverrini.
Biltricide is contra-indicated in patients who previously have shown hypersensitivity to the drug or any of the excipients.
Since parasites distruction within the eye may cause irreversible lesions, ocular cysticercos must not be treated within this copmound
Gastro-intestinal and abdominal pains.
Nausea and Vomiting
Monitor for clinical manifestations of Mazzotti reactions(arthralgia/synovitis, enlargement and tendreness of auxillary cervical, inguinal and other lymph odes, skin involvement including edema,papular and pastular or frank urticarial rash, fever.)
Store aat room temperature below 30 degrees
Protect from light nd excessive humidity.