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How do drugs work through receptors (1 (Quantitation (Drug interaction…

- - - - Binding
        
        Shape
        
        Attractive forces
        
        1/d
        
        balance strength and range
        
        Mass Action
        
        The rate of a chemical reaction is proportional to the concentrations of the reactants
        
        drug (A) >>>>>>>>#receptor (R)
        
        rate = product * constant
        
        Fractional receptor occupancy
        
        [AR]/[R}t
        
        =0.5 when A= KA
        
        Occupancy ~= response
        
        1 more item...
      - Affinity
    - - Agonism
      - efficacy
    - - Comp
      - non-comp
- - - - high affinity
      - high efficacy
    - - Lots of receptors
      - Efficient S-R coupling
  - - - Competitive
      - non-competitive
        
        receptor
        
        Allosteric
        
        not receptor
        
        Pathway inhibitors
        
        functional (physiological) antagonists
- - - - initial treatment for opiate dependency
    - - B2-adrenoceptor selective partial agonist