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Aspirin (History of aspirin (In the 19th century (1838 Isolation of…
Aspirin
History of aspirin
In the 18th century
Edward Stone performed a clinical trial of the willow bark
In the 19th century
1838
Isolation of salicylic acid from salicin
1897
Adding an acetyl group to salicylic acid creates a more pure and stable compound
1899
Bayer named the compound aspirin
3000 BC
Extracts derived from the willow plant’s leaves
600 BC
Medicinal knowledge spread to the Babylonians
500 BC
Medicinal knowledge spread to the Chinese
Link:
https://www.pharmaceutical-journal.com/news-and-analysis/infographics/a-history-of-aspirin/20066661.article
Chemistry of aspirin
How aspirin is made from salicylic acid
Salicylic acid is reacted with an excess of acetic anhydride
Link:
http://www.lahc.edu/classes/chemistry/arias/Exp%205%20-%20AspirinF11.pdf
NMR
Explain the peaks
Link:
http://sdbs.db.aist.go.jp/sdbs/cgi-bin/direct_frame_top.cgi
IR
Explain the peaks
Link:
http://sdbs.db.aist.go.jp/sdbs/cgi-bin/direct_frame_top.cgi
How aspirin works
Aspirin acts by inhibiting the production of prostaglandins
Link:
https://www.britannica.com/science/aspirin
Pharmacology of aspirin