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Acute Asthma Exacerbation (Pathophysiology (Cytokines are released,…
Acute Asthma Exacerbation
Epidemiology
Females more affected than males
Approximately 4000 deaths annually
Over 65,000 hospital admissions per year
Pathophysiology
Cytokines are released
Dendritic cells activate TH2 cells
Production of antibodies (IgE) bind to mast cells
Exposure to antigen in airway
Granules are released
Bronchospasm and mucus production occurs
Clinical Presentation
shortness of breath
Hypoxia
Wheezing
Possible respiratory arrest
Diagnosis
PFTs
ABGs
Physical assessment
Review of Symptoms
Treatment
Supplemental oxygen
Possible advanced airway
Bronchodilators and anticholinergic medication
Allergen removal