Please enable JavaScript.

Coggle requires JavaScript to display documents.

Arteriosclerosis (Atherosclerosis (Affects the Intima (Plaque consists of…

- - - - Can often be calcified
  - - - HTN, smoking, diabetes, hypercholesteremia
        
        HDL decreases risk
    - - Age
      - Gender
        
        increased in males and post menopausal females
        
        estrogen is protective
      - genetics and family history
  - - - Lipids are oxidized and consumed by macrophages resulting in foam cells
        
        fatty streaks ( flat yellow lesions of intimal consisting of lipid stuffed macrophages)
        
        progresses to atherosclerotic plaque
  - - - Impaired blood flow and ischemia
        
        Peripheral vascular disease
        
        Angina
        
        Ischemic bowel disease
      - Plaque rupture with thrombosis results in myocardial infarction and stroke ( MCA)
      - Plaque rupture with embolization results in atherosclerotic emboli characterized by cholesterol crystals
      - Weakening of vessel wall result in aneurysm
- - - - consequence of malignant hypertension
        
        reduced vessel caliber with end-organ ischemia
        
        may lead to fibrinoid necrosis (death of blood vessel wall) with hemorrhage; classically causes acute renal failure with flea-bitten appearance
  - - - Proteins are seen as pink hyaline
      - Consequence of benign hypertension or diabetes
        
        reduced vessel caliber with end-organ ischemia
        
        arteriolonephrosclerosis
        
        chronic renal failure