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Fibrous & Globular Proteins (Globular (Pepsin (Digests protein in the…
Fibrous & Globular Proteins
Keywords
Fibrous protein: Relatively long/thin structure, insoluble in water, often having a structural role
Globular protein: Relatively spherical, soluble in water, often having a metabolic roles
Prosthetic group: Non-protein component that forms a permanent part of a functioning protein molecule
Fibrous
Regular, repetitive sequences of amino acids
Usually insoluble in water
Enable them to form fibres which tend to have a structural use
Collagen
Proves mechanical strength in artery walls and tendons
Forms bones, cartilage/connective tissue
Keratin
Found in nails/teeth/claws etc
Elastin
Strong/extensible due to cross linking etc
Found in skin/lungs etc
Globular
Tend to roll into spherical shape
Hydrophobic R groups turned in
Soluble in water
Specific shapes
Haemoglobin
Quarternary structure
Oxygen bind to iron in each of the four haem groups
Insulin
Two polypeptide chains joined by disulfide links
Binds to glycoproteins' receptors on the outside to increase uptake of glucose
Pepsin
Digests protein in the stomach
43 acidic R group amino acids (stable in acidic environment)
Held together by two disulfide links and hydrogen bonding