Please enable JavaScript.
Coggle requires JavaScript to display documents.
regub 21: reproductive pharmacology (ii) (Hormonal contraceptives…
regub 21: reproductive pharmacology (ii)
Mifepristone
antiprogestogen
competes with hormone @ R UNLESS hormone is absent (will then be a partial agonist)
use = abortion
up to 7 wks
alternative to surgery
used with a PGE1 agonist (e.g. misoprostol), which induces contractions
Hormonal contraceptives
oral
combined pill
99.5% reliable
oestrogen + a progestogen
take for 21 days, break for 7
MOA: inhibits gonadotropins, no follicular development or ovulation. Mucus inhospitable to sperm (change pH + viscosity)
mono/bi/tri phasic
progestogen only (mini) pill
99% reliable
daily admin
MOA: inhibits LH, no ovulation, mucus inhospitable to sperm
irregular menses, amenorrhoea, increased ovarian cyst risk
metabolised by CYP450 enzymes in liver
! interference: CYP-inducing antibiotics, seizure medication, st John's wort
Long acting progestogen
high dose IM every 3 months
not suitable long-term: decreases bone density
progestogen subnormal implant
etonogestrel
3 yrs
headaches
emergency contraception
MOA: delay ovulation, thicken cervical mucus
does not work after implantation
levonorgestrel
must be taken in 3 days
nausea + vomiting
weight affects efficacy (obese -> higher dose)
Ulipristal acetate
must be taken in 5 days
progesterone R modulator