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ANTHELMINTIC DRUGS (Albendazole (mechanism of action (causes degenerative…
ANTHELMINTIC DRUGS
Albendazole
mechanism of action
causes degenerative alterations in the intestinal cells of the worm by binding to colchicine sensitive site of Beta tubulin thus inhibiting its polymerization or assembly into microtubules its binds much better the beta-tubulin of parasites than in that of mammals.
indications
pinworm disease, useful for giardiasis, trichuriasis, hydatid disease
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storage
store in room temperature in a air tight container, keep away fro light
contraindications
contraindicated to pregnant and breastfeeding women, liver impairment.
side effects
vomiting, nausea, abdominal pain, headache, dizzness, temporary hair loss
Biltricide
mechanism of action
works by causing severe spasm and paralysis of worms muscle, increases the permeability of the membrane of the schistome cells towards calcium ions, the drug thereby induces contraindication of the parasites, resulting in paralysis in contracted state
indications
to treat infections due to all species of schistosoma, and infection due to liver flukes
srorage
store it in a closed container at room temperature, away from heat, moisture and direct light
contraindications
contraindicated in patients who previously have shown hypersensitivity to the drug or ant of other excipients, and ocular cysticercosis
side sffects
headache, tiredness, weakness, nausea,, loss of appetite, joints/muscle pain, dizzness
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Diethylcarbamazine
mechanism of action
an inhibitor of arachidonic acid metabolism in microfilaria, results in the sequestration of microfilaria and eventual destruction by the immune system, sensitizing micrafilaria to phagocytosis
indications
to treat filariasis, including lymphatic filariasis, tropical pulmonary, eosinophilia and loiasis
contraindications
kidney disease, pregnancy,lower seizure threshold
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storage
store in a tightly closed container, at room temperature, protect from excess heat, light and moisture, keep out of reach of children
side sffects
increased heart rate, dizzness, nausea, vomiting, loss of appetite, chills and fever, muscle and joint pain.