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cce_psychiatry_schizophrenia (social (psychoeducation, family support,…
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risk factors (genetic: family history of schizophrenic, schizoid personality)
risk factors (environmental: life events, high expressed emotion, substance abuse, congenital infections, perinatal hypoxia)
psychoactive: alcohol, amphetamines, cannabis, cocaine, hallucinogens
iatrogenic: anti-parkinsonism, corticosteroids, anticolinergics
ensure compliance: frequent follow-up, community psychiatry nurse, depot injection
6-8 weeks, not helpful: 1 clarify diagnosis 2 any co-morbidities e.g. substance abuse 3 compliance
4 increase dosage, add 1 more antipsychotic
5 (2 antipsychotics, one is atypical antipsychotic) (adequate dosage, adequate duration) (good compliance) TREATMENT-RESISTANCE SCHIZOPHRENIA
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-not helpful (augmentation: clozapine + high D2 affinity e.g. risperidone, sulpiride, amisulpiride) (other second generation antipsychotics not yet tried)
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