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Mesenchymal Lesions (Bone (Others: (Osteoid osteoma, Osteoblastoma,…
Mesenchymal Lesions
Bone
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Osteoma
Represented as:
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Tori and exostosis are histologically identical but not considered osteomas
--> As confirmed with documentation of continued growth
Clinically
- Surface of the bone as sessile or polypoid mass (periosteal osteoma)
- Within the medullary bone (Endosteal osteoma)
Histologically
dense lamella bone, which can be distinguished from normal bone
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Vascular
Vascular Malformations
Structural anomalies of blood vessels without endothelial proliferation (persistent throughout life)
Categorized according to type of vessels: Capillary, Venous, Arterial
Haemangioma
"Tumor of infancy"
Characterized by rapid growth phase of endothelial cells proliferation, followed by gradual involution
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Others:
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Kaposi's sarcoma
Opportunistic infection which causes malignant lesions in the lymphovascular system, these are visible under the skin
Common in HIV/AIDS patients
Neural
Neurilemmoma
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Clinically
- Slow-growing, encapsulated
- Usually asymptomatic
- Tongue is the most common oral site
- Appear as uni/ multilocular radiolucency
Histologically
Antoni type A
- Verocay bodies - palisading nuclei w/duplicated basement membrane
- Streaming fascicles of spindle-shaped cells
Antoni type B
- Less cellular and less organized
- Spindle cells are randomly arranged within loose, myxomatous stroma
Neurofibroma
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Clinically
- Slow growing soft and painless
- Skin is most commonly affected - Intraorally: tongue and buccal mucosa
Histologically
- Well circumscribed
- Interlacing bundles of spindle-shaped cells w/ wavy nuclei
- Delicate fibro-cartilage myxoid matrix
Traumatic neuroma
Damaged neuro elements, haphazardly proliferative, throughout the muscular area, reactive, painful
Adipose
Lipoma
Benign Tumor of the fat
occurs mostly in obese people, completely unrelated to fat embolism
- Characterized by lobulation (fat lobules)
= mononuclear, non-bizarre nuclei (of mature adipocytes that do not differ from normal fat)
- Encapsulated – a rim of fibrous c.t. surrounding the locule
Asymptomatic = soft, smooth surfaced nodular mass
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Others:
- Osseous (osteolipoma)
- Cartilaginous (Chondrolipoma)
- (Fibrolipoma) fibrous tissue
- (Myxolipoma) myxoid change
- Intramuscular Lipoma
Shows an infiltrative growth pattern encasing skeletal muscle fibers that often show atrophy
Fibrous
Fibromas
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Pyogenic Granuloma
Inflammatory lesion = Granulation tissue replacing endothelial cells – lots of infla. Infiltrate, similar to a healing response
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