Please enable JavaScript.

Coggle requires JavaScript to display documents.

Innate Immunity (Cytokines (IL-1 (Endothelial actiation (leukocyte…

- - - - leukocyte recruitment
  - - - leukocyte recruitment
  - - - INF a
        INF B
        
        NK activation
        
        Increased MHC I expression
        
        Anti-viral replication
    - - INF gamma
        
        Macrophage activation
  - - - Decreased cytokine/chemokine
      - Reduced MHC class II
- - - - lipid layer
  - - - Bind bacteria, create pores, disrupt equilibrium
      - Location
        
        Mucosal layer
    - - Lysosymes
- - - - Pathways
        
        Classical
        
        Response time
        
        5-7 days after
        first exposure
        
        Immediately after 2nd exposure
        
        Activated by:
        
        antibodies
        
        bind pathogen
        Activate C1 protease
        
        C1 cleavage
        
        1 more item...
        
        Lectin
        
        Response time:
        
        24-48 hrs
        
        Activated by:
        
        Mannose-binding lectin (MBL)
        
        MBL binds pathogen
        Activates MASP proteae
        
        C2, C4 cleavage
        
        1 more item...
        
        Alternative
        
        Response time
        
        Immediate
        
        Activated by:
        
        Bacterial surfaces
        
        Factor D Protease
        
        C3 , factor B cleavage
        
        1 more item...
    - - C5a, C3a
    - - C5a, C3a
    - - Phagocytosis
        
        C3b
  - - - Stabilizes C3 convertase
        
        Promotes activity
    - - Prevent C3 convertase formation
        
        Neg regulator
    - - Host cell membranes
        
        Neg regulator
    - - Neg regulator, classical
    - - Prevents C9 binding
        INhibits MAC formation
        
        Neg regulator
- - - - Cyto/chemokine release
        Endothelial activation
        
        Diapedesis
        
        PMN chemotaxis
        
        Selectins
        
        slow rolling
        
        Integrins (LFA-1)
        
        strong adhesion to ICAM
  - - - Phagocytes
        
        Phagolysosome
        
        Acidification
        
        Oxygen radicals
        
        Nitrogen radicals
        
        Defensins
        
        Lysozyme
      - Death by NETosis
    - - Tissue residents
        
        Kupffer cells
        
        Osteoclasts
        
        Dust cells
        
        Microglia
      - Phagocytes
    - - Parasitic defense
        
        Helminths
        
        Histamines
        Proteases
        lipases
        DNases
    - - IgE triggered
        
        Parasites, allergies
        
        Vasodilators
        
        Histamine
        heparin
    - - Tissue residents
        
        Activated by Ab's or TLR's
        
        histamine
        leukotrienes
        prostaglandsins
        
        Allergic responses
- - - - Liver
        
        Acute phase proteins
        
        C-reactive protein
        MBL
        Hepcidin
        C3, C4, C9, Factor B
        GCSF
        Fibrinogen
        Plasminogen
- - - - Recognized by:
        
        CE14
        
        TLR4
        
        NFkB
        
        cytokine production
        
        MD2