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[Naproxen] Screen Shot 2018-03-16 at 2.35.44 PM (Pharmacokinetics…
[Naproxen] 
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Clinical Considerations
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Advanced Renal Failure
Reduced prostaglandin synth, reducing renal blood flow which may cause renal decompensation
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Toxicities
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Multiple cytochrome P450 isoforms (P450 1A2, 2C8 and 2C9) appear to be involved in naproxen demethylation
metabolically activate biologically inert compounds to electrophilic derivatives that can cause toxicity
Patients with significant toxicity who develop severe acidosis may require supportive treatment with intravenous sodium bicarbonate