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gihep 10: GIT hormones (ii) (splanchnic/GIT blood flow (increased by CCK…
gihep 10: GIT hormones (ii)
splanchnic/GIT blood flow
increased by CCK,gastrin,secretin
decreased by somatostatin
histamine increases local mucosal BF
VIP causes vasodilation in mucosa to increase BF
Long-term control of food intake
hypothal
inhibitory inputs
decrease intake
insulin,amylin,leptin,CCK,peptide YY (after high protein meals),vagal afferents
inhibit orexigenic (hunger) neurons
stimulatory inputs
increase intake ... ! obesity
Ghrelins
gastric peptides
rise before meals, fall after
Dopamine
feeding motivation (reward)
NO GLANDS
enteroendocrine cells only
secrete hormones into blood to act on distant cells
scattered in mucosa
most dense @ pyloric antrum (secrete gastrin here)
20 known GIT hormones, not all functions known