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Protein (Tertiary structure (Stabilized by (Hydrogen bond (affinity of H…

- - - - structurally independent segments that have specific f(x)
  - - - affinity of H atom to N/O atoms
    - - oxidative coupling of cysteine side chan
    - - charged side chains attracted to - charged side chain
- - - - Long, rod shaped molecules
        
        Keratin
    - - Compact, spherical molecules
        
        Enzymes, immunoglobulin, hemoglobin
  - - - Contains only amino acid
        
        Keratin
        
        Serum albumin
    - - simple + prosthetic group
        
        Phosphoproteins
        
        Lipoproteins
        
        Glycoproteins
- - - - alpha-helix
        
        Forms spontaneously
        
        Lowest energy & most stable
        
        Proline :red_cross:
        
        Rigid ring prevent N-C(alpha) bond from rotating
        
        No N-H group available
        
        Glycine :red_cross:
        
        R group too small - polypeptide chain too flexible
        
        Polypeptides chain twist into right handed helical conformation
        
        amino acid sequence w large number of charged amino acids :red_cross:
        
        Glutamate
        
        Aspartate
        
        Bulky R group :red_cross:
        
        Tryptophan
      - beta-pleated
        
        2/> polypeptide chain segment line up side by side
        
        Each individual segment - beta-strand
        
        Parallel
        
        p.chain in same direction
        
        Antiparallel
        
        p.chain in opposite direction
        
        More stable - fully colinear hydrogen