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Glycogen metabolism and the pentose phosphate pathway (Pentose Phosphate…
Glycogen metabolism and the pentose phosphate pathway
Glycogen degradation
Pentose Phosphate Pathway
Sythesis, Detoxification
Oxidative phase of PPP
Glicose 6-phosphate is metabolized by both the glycolytic pathway and the pentose phosphate pathway
The rate of PPP is controlled by the concentration pf NADP+
The need for ribose 5P is greater than the need of NADPH
The need for NADPH and ribose 5P are balanced
Glucose 6P dehydrogenase lessens oxidative stress
Glucose 6-phosphate dehyfrogenase deficiency causes a drug induced hemolytic anemia
Malaria medication : pamaquine, primaquine, and vince should not be given to individuals with G-6PD
Glycogen breakdown requires enzyme
A debranching enzyme is needed for the breakdown of glycogen
Phosphoglucomutase
Liver contains glucose 6-phosphate, a hydrolytic enzyme absent from muscle
Phosphorylase is regulated by allosteric interactions and reversible phosphorylation
Ephinephrine and glucagon signal the need for glycogen breakdown
Glycogen depletion coincides with the onset of fatigue
Glycogen is synthesized and degraded by different pathways
Glycogen synthase, Glycogenin, Branching enzyme
Glycogen breakdown and synthesis are reciprocally regulated