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TB drugs (rifampin (uses (prophylaxis for close contacts of (N. menintitis…
TB drugs
rifampin
MOA
inhibits RNA pol
uses
TB
prophylaxis for close contacts of
N. menintitis
H. influenza
SE
stim CYP450
organge body fluids
(harmless)
Isoniazid
MOA
inhibit mycoloc acid synthesis
prodrug acitivated by KatG
(catalase-peroxidase)
resistance: inhibit Kat-G
promotes B6 (pyrodoxine excretion)
give with B6 to prevnet Se
SE
peripheral neuropathy
seizures
hepatotox
(slows acetylation)
asymp inc in LFT
lupus
anion gap met acidosis
(mudp"i"les
ethambutol
MOA
inbhibit arabinosyl transferase
blocks cell wall carb formation
SE
optic neurits
red-green color blindness
pyrazinamide
SE:
hyperuricima=gout
all hepatoxic