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(1) Biofilm (Process (1) Pellicle Formation
Tooth Surface
Protein &…
(1) Biofilm
Process
1) Pellicle Formation
- Tooth Surface
- Protein & Glycoprotein adsorbed
2) Transport of Bacteria to Pellicle
- Saliva Flow
- Movement of cell (Chemotaxis)
- Particles in motion (Brownian movement)
3) Attachment of Bacteria to Pellicle
- VDW / H-bonding
- Covalent / Ionic / Electrostatic
- Irreversible: Surface adhesin to receptor
- Primary Colonizers: Streptococci, Actinomyces (Mutans Streptoccoci - Big Group)
- Oralis
- Mitis
- Sanguinis
- Parasanguinis
- Gordonii
4) Aggregation of new bacteria to old bacteria
- Surface
- Pellicle (Protein/Glycoprotein)
- Primary Colonizers
- Fusobacterium Nucleatum (Bridge)
- Large SA
- Stabilize complex
- Promiscuous
- Late Colonizers
5) Detachment allows new colonization
- Shear force
- S.Mutans enzymes to cleave proteins from surface
- Environmental factors
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Methods of communication
Quorum Sensing
- Positive feedback (Quorum molecules)
- QM pumped out, diffuse into cell
- Coordinated behaviour
Metabolic
- Bi-product/excretion used by others
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Clinical Implications
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Consequences
1) Neutrophils cannot penetrate
- Superoxide/Acid damage host
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