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MnSOD development (If present (Active at the levels normally seen…
MnSOD development
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If absent
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KO data seems to support absence but then CuZNSOD could compensate so difficult to draw a firm conclusion
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Complex III Q site
Proposed to make production at the Q site far more favourable by pulling the reaction to towards O2.- production because it contrains its levels to picomolar
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Interesting implications for signalling if so--one way to make it favoured is to remove the O2.- but difficult to bypass in some sites owing to charge restriction.
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KO
Lethal only post-partum as a result of defects in oxidative tissues (brain, hear and muscle).
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