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VASCULITIS (SYMPTOMS (FEATURES (Neurological (chorea,, psychosis,, fits,,…
VASCULITIS
SYMPTOMS
Different vasculitides preferentially affect different organs, causing different patterns of symptoms
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If presentation does not fit clinically or serologically into a specific category consider malignancy-associated vasculitis
severe vasculitis flare is a medical emergency; organ damage may occur rapidly (eg critical renal failure <24h).
FEATURES
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GI
Pain or perforation (infarcted viscus),
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Neurological
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Arteritis of the vasa nervorum (arterial supply to peripheral nerves) may cause mononeuritis multiplex or a sensorimotor polyneuropathy
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TESTS
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Urine: proteinuria, haematuria, casts on microscopy
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MANAGEMENT
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Medium/small:
immunosuppression (steroids, ± another agent, eg cyclophosphamide if severe, or methotrexate/azathioprine depending on features).
inflammatory disorders of blood vessels; commonly classified using the modified Chapel Hill criteria
can affect any organ, and presentation depends on the organs involved
may be a primary condition or secondary to other diseases, eg sle, ra, hepatitis b & c, hiv