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Antibiotics (RIBOSOMES (LINEZOLID, AMINOGLYCOSIDES, CHLORAMPHENICOL,…
Antibiotics
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NUCLEAR MATERIAL
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FQs
- bateriacidal against G-ve and G+ve
- later gens have greater oral bioavailability
- versatile for systemic infections
- broad spec
- distribution/lipophilicity
- side effects
- NSAIDs = convulsions
- QT interval
- mechanism:
- binds ot bacterial DNA gyrase and topo 4
- inhibits unwinding of DNA supercoils
- resistance:
- alterations to dna gyrase and topo 4
- decreased uptake or increased efflux
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