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Acantholytic diseases (Dariers disease (Background (AD inheritance, 1:30…
Acantholytic diseases
Dariers disease
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Histo
Acanthyolysis in spiny, granular and cornified layers
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Corps ronds - solitary cells with pyknotic nuclei, perinuclear halo and bright pink cytoplasm
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Hailey-Hailey
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Background
2-4th decade usually, but can be seen in kids
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AD, ATP2C1 gene. 1/3 sporadic
Neonatal pemphigus
Transplacental passage of autoantibodies against interccellular substance from mother with pemphigus vulgari
Presents at birth with bullae, vesicles and erosions
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Pemphigus vulgaris
Clinical
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Flaccid bullae, spontaneous occurrence, breaks leaving erosions
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Face, scalp, axillae and mouth most common
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