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ATHEROSCLEROSIS (PATHOGENESIS (RESPONSE TO INJURY HYPOTHESIS (Postulated…

- - - - shortlived injury --> endothelial function restored
        repeated injury --> plaque development --> ENDOTHELIAL DYSFUNCTION --> higher permeability --> lipid platelet, monocyte adhere to endothelium --> intima
      - monocytes-->macrophage-ingest lipids-> foam cells
- - - - Hyperlipidaemia
      - Hypertension
      - Cigarette smoking
      - DM
- - - - Acute
      - Chronic
- - - - Precursor of arethromatous plaque
      - Composed of lipid-filled foam cells
    - - Calcification
      - Ulceration
      - Plaque haematoma
      - Superimposed thrombosis
      - Aneurysmal dilatation
- - - - CELLS
        
        Macrophages
        
        Smooth Muscle
        
        Leukocytes
      - ECM
        
        Collagen
        
        PG