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REGUB2: Cellular Mechanisms of Hormone Action (ii) (Insulin R (tetramer,…
REGUB2: Cellular Mechanisms of Hormone Action (ii)
Insulin R
tetramer
ligand activated
tyrosine R
after insulin binds, R autophosphorylates
SH2 proteins bind
Hormone R defects
can cause disease...
type 2 diabetes mellitus
less Rs
signalling problems
diabetes insipidous
vasopressin R mutation
Graves'
autoantibodies to TSH R
increased hormone production - hyperthyroidism
Enzyme linked immunosorbent assay (ELISA)
uses antibodies + colour change to identify substances
types....
direct
indirect
sandwich
measures amount of bound conjugated antibody
hyperbolic graph (high y=high conc)
Competitive
measures amount of bound conjugated substrate
backwards sigmoid graph (high y=low conc)
sandwich + competitive methods can detect conc of a substance