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immunesuppressant drugs (IMDH inhibitors (azathioprine (nursing…

- - - - side effect
        
        burning with urination or dysuria
        
        sore throat
        
        loss of appetite
        
        fever, night sweat,weight loss, tiredness
      - Route
        
        administered orally
      - contraindication
      - storage
        
        25 degrees celcius
    - - azathioprine antagonizes purine metabolism and may inhibits synthesis of DNA, RNA and proteins. It also interferes with cellular metabolism and inhibits mitosis. Its mechanism of action is likely due to incorporation of thiopurine analogues into the DNA structure, causing structure, termination and cytotoxicity
    - - prevention of rejection in renal homotransplantation
      - rheumatoid arthritis
      - homotransplantation
- - - - mechanism of action
        
        sirolimus inhibit T lymphocytes activation and proliferation that occur in response to antigenic and cytokine, stimulating by mechanism that distinct of other immunosuppressants. Sirolimus also inhibit antibody production. In cell sirolimus bind immunophilins, fk binding protein -12 to degenerate an immunosuppressive complex.This complex binds to and inhibit the activation of mammalian targets of rapamycin (mTOR)
      - nursing considerationm
        
        side effect
        
        abdominal pain
        
        black or tarry stool
        
        accumulation of pus
        
        changes in skin
        
        Route
        
        administered orally
        
        contraindication
        
        contraindicated to patiens with eseconditions
        
        high cholesterol
        
        liver problems
        
        malignant tumor
        
        kidney disease
        
        disease caused by cytomegalovirus infection
        
        fluid retention
        
        pneumonia caused by pneumocystis jirovecii
        
        storage
        
        25 degrees celcius
      - indications
        
        prophylaxis of renal transplant rejection
        
        lymphanglolelomymatosis
- - - - side effect
        
        sore throat, coughing or signs of infection
        
        dizziness, headache, swelling of feets
        
        fever or chills
      - storage
        
        the prefilled syringe should be be stored in refrigerator between 2 to 8 degrees Celsius. it must not be frozen of be exposed to temperature above 30 degrees celcius
      - contraindication
        
        contraindicated to patient with liver impairment,elevated ALT, AST and autoimmune hepatitis
      - route
        
        intravenously and subcutanously in treatment of multiple sclerosis
    - - Daclizumab function binds with high-affinity IL-2 receptor complex and inhibit IL-2 receptor sub-unit is expressed on activated but not resting lymphocytes
    - - prophylaxis of acute organ rejection
      - multiple sclerosis
- - - - side effect
        
        elevated blood pressure
        
        unusual growth or swelling in gums
        
        unusual hair growth, headach
        
        nausea or vomiting, diarrhoea
      - Route
        
        administered orally
      - contraindication
        
        allergic to cyclosporine and these conditions
        
        severe or uncontrolled Blood pressure
        
        A mother who is breast feedimg
        
        High amount of bilirubin in blood
        
        malignant lymphoma
        
        seizures
      - Storage
        
        25 degrees celcius
    - - calcineurin activates transcription of IL 2 (interleukin 2)
        ciclosporin binds with cytosolic cyclophilin to form a complex which inhibits calceneurin
    - - Kidney, liver, heart transplant rejection