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corticosteroids (fludrocortisone acitate (Nursing consideration…
corticosteroids
fludrocortisone acitate
indications
prophylactic management of asthma, Addison's disease, adrenogenetic syndrome, primary and secondary adrenocortical insuffieciency
mechanism of action
Fludrocortisone bindd the mineralocorticoids receptors(aldostero receptor). The binding or activation of mineralocorticoids receptors by fldrocortisone in turn causes an ion and water transport and thus raises extracellular fluid volume and blood preasure and lowers potassim level.
Nursing consideration
Contraindications
Fludrocortisone must not be given to patients with fungal infection,thyroid disorder,renal impairment, active infection and those who are allergic to fludrocortisone acitate
Side effect
insomnia, eye bruising, increase hair growth,irregular menstrual periods or amenerrhoa, dizziness
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Hydrocortisone(IV)
Nursing consideration
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side effect
Headache, menstrual period changes, weight gain nausea, increased sweating, unusual hair growth on your face and body, muscle weakness, loss of appetite
contraindications
Hydrocortisone must not be given to patient who is taking herbal medication and those who are allergic to it
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indiccations
Relief inflammatory and pruritic manifestations of corticosteroids- responsive ( adrenal insufficiency, Addison's disease). it is also used to treat immune and allergic disorder such arthritis, lupus, severe psoriasis, sever asthma, ulcerative colitis and Crohn's disease
mechanism of action
therapeutic Hydrocortisone is a synthetic or semi-synthetic analog of natural hydrocortisone hormone produced by the adrenal gland with primary glucocorticoid and minor mineralocorticoids effect. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability renal excretion of calcium and suppress immune and inflammatory response
Methylprednisolone
Nursing consideration
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contraindications
it must not be used to patient with fungal infection, ulcerative colitis, liver disease, multiple sclerosis
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mechanism of action
methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Unbound glucocorticoids cross cell membrane and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism , glucocorticoids inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, suppress humoral immune response.
Indications
Endocrine disorder for example congenital adrenal hyperplasia,hypercalcemia associated with cancer and nonsuppurative thyroiditis. Allergic state for example bronchial asthma, contact dermatitis and seasonal or perennial allergic rhinitis
prednisone
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nursing consideration
side effects
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acne, increased sweating dry skin
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nausea, stomach pain, bloating stomach
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mechanism of action
prednisone is a glucocortocoid receptor agonist. it is metabolized first in the liver it active form prednisolone . prednisolone crosses cell membrane and bind with high affinity to specific cytoplasmic receptor. This inhibit leukocyte infiltration at the site of inflammation an suppress humonal immune responses and reduction of oedema or scar tissue.