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Antivirals (5.Replication Inhibitors (ACYCLOVIR, VALACYCLOVIR, PENCICLOVIR…
Antivirals
5.Replication Inhibitors
ACYCLOVIR, VALACYCLOVIR, PENCICLOVIR, FAMCICLOVIR, GANCICLOVIR, CODIFOVIR
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Adverse effects: Neurotoxicity, nephrotoxicity, CIDOFOVIR is mutagenic
Clinical Indication: Chickenpox, Shingles, Cold sores
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3.Uncoating Inhibitors
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Blocks viral proton channel, M2 which is only present in Influenza A and not Influenza B
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Must be used within 2 days of infection. SE:- urinary retention, CNS effects but can be reduced using RIMANTADINE
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7.Budding and Release
NEURAMINIDASE INHIBITORS
ZANAMIVIR- inhalation, can cause bronchospasm
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